GH Peptides and Our Philosophy
Healthy living is an essential concern to all of us, and the drive to improve our well-being is as vital as it is universal. An invaluable part of this relentless pursuit is driven by clinical research involving growth hormone peptide compounds such as Growth Hormone Releasing Hexapeptide and Ipamorelin. That's why we at GHPeptides.com are committed to offering only the highest quality peptides for research and laboratory applications. Our company maintains a vigorous passion for investigation and discovery shared by the thousands of researchers worldwide that have made us their exclusive peptide supplier. At GHPeptides.com we're fervently engaged in the quest to uncover the exciting possibilities presented by the utilization of peptides in future therapeutic applications, and we're dedicated to doing our utmost to provide only the best quality peptides, such as Hexarelin, to researchers striving to unlock the potential of these extraordinary peptides.
What is HPLC (High Performance Liquid Chromatography)?
HPLC is a technique in analytic chemistry used to separate, identify, and to quantify each component in a mixture. HPLC is basically a highly improved form of column chromatography. Instead of a solvent being allowed to drip through a column under gravity, it is forced through under high pressures of up to 400 atmospheres. That makes it much faster and allows you to use a smaller particle size for the column packing material, which gives a much greater surface area for interactions between the stationary phase and the molecules flowing past it. The other major improvement over column chromatography concerns the detection methods which can be used. These methods are highly automated and extremely sensitive.
GHRP-2 vs GHRP-6
GHRP-2 (Growth Hormone Releasing Peptide 2) and GHRP-6 (Growth Hormone Releasing Hexapeptide) are both growth hormone releasing peptides, which excites the hypothalamus and causes a high release of GH (growth hormone) which tapers back to normal levels a few hours after administration. The GH pulse mimics the natural pulse of the human body. GHRP-2 stimulates growth hormone by maintaining the highest elevations in growth hormone over greater periods of time. It has also been noted that GHRP-6 stimulates hunger while GHRP-2 does not. Lastly, it has been observed that GHRP-2 raises cortisol, prolactin, and aldosterone levels more than GHRP-6. Cortisol is a hormone related to stress, while prolactin is a hormone which has the possibility of diminishing sex drive, and aldosterone is a hormone that promotes water retention.
Additive Free and Highly Purified Peptides
No matter what the industry, the quality of a business’s product offering is always of paramount importance to the consumer. When it comes to the online purchase of peptides, it’s clear that there is no substitute for obtaining only the most pure and highest quality peptides. Lower quality peptides can be ridden with fillers like mannitol that can greatly impact your research results. Don’t sacrifice time and money for an inferior product; make sure that you only buy peptides of premium quality available from GHPeptides.com. Our company spares no expense in ensuring that our peptides are of the highest possible purity and quality.
IGF-1 (Insulin-Like Growth Factor-1) and Muscle Growth
It is widely acknowledged that IGF-1 (Insulin-Like Growth Factor-1) is a powerful stimulator of muscle growth. Still, many are unaware of how IGF-1 (Insulin-Like Growth Factor-1) exerts this effect on muscle tissue. While IGF-1 (Insulin-Like Growth Factor-1) supports the growth and retention of existing muscle tissue, it also promotes the growth of new muscle cells and fibers. The ability of IGF-1 (Insulin-Like Growth Factor-1) to additionally stimulate muscle cell proliferation underlies its potent anabolic nature and differentiates it from other muscle-building agents. When an individual experiences certain muscular stimulation such as that caused by weight training, the body’s response involves a process called hypertrophy, which is an increase in the size of muscle cells already in existence. Importantly, this process affects only existing muscle cells. That is, only those muscle cells currently existing in the body increase in size; new muscle cells and fibers are not created. Indeed, the adult body has only a fixed number of muscle cells that may grow in this manner. However, studies have demonstrated that administration of IGF-1 (Insulin-Like Growth Factor-1) in study subjects results in an increase in both the size of existing muscle cells as well as the development of new muscle cells (hyperplasia) and growth of new muscle fibers (mitogenesis). Studies have shown that muscular growth increases dramatically in the presence of IGF-1 (Insulin-Like Growth Factor-1) administration, and these newly developed muscle cells increase in both size and density. Clinical research has established that IGF-1 (Insulin-Like Growth Factor-1) is largely unique among other anabolic agents in its ability to promote hyperplasia and mitogenesis, adding yet another dimension to its remarkable list of effects.
What are peptides?
A peptide is a chain of amino acids linked to one another by amide (peptide) bonds. A peptide bond is the covalent chemical bond formed when the carboxyl group of one amino acid reacts with the amino group of another. The word peptide is derived from the greek word πέσσειν, which means “to digest.” Peptides are an essential part of nature and there are thousands of them that occur naturally in the human body and in animals, but new synthetic peptides are being discovered daily, which show a promising future for health and drug development. The benefits of peptides on health have been demonstrated in numerous research studies related to neurological function, anti-aging, muscle growth, skin wrinkles, growth hormone deficiency and so forth.
How are Peptides Made?
Peptides are made both naturally (within the body) and synthetically (via peptide synthesis). Ribosomal peptides and non-ribosomal peptides are manufactured inside the organism. Synthetic peptides are made via liquid-phase peptide synthesis or solid-phase peptide synthesis techniques to ensure maximum requested purity. Numerous peptide suppliers offer custom peptide synthesis of numerous sequence lengths and modifications.
What is the difference between a peptide and a protein?
Peptides are commonly distinguished from proteins based on size, with a general rule of thumb being that a peptide is 50 amino acids in length or less. A polypeptide is a long, unbranched, and continuous strand of amino acids forming a peptide chain. Proteins consist of one or more polypeptides arranged in a biologically functional way. Proteins are quite often bound to ligands, another protein, other macromolecule (DNA, RNA, etc.), or to complex macromolecular assemblies. Many proteins, such as insulin or thymosin beta-4 for example, are commonly referred to as peptides, but they are proteins by definition.
Number of Amino Acids
The shortest peptide length is two amino acids and is known as a dipeptide. A peptide of three amino acids is a tripeptide, a peptide of four amino acids is a tetrapeptide, etc. An undecapeptide has eleven amino acids, a dodecapeptide has twelve amino acids, a tridecapeptide has thirteen amino acids, etc. An icosapeptide has twenty amino acids, a tricontapeptide has thirty amino acids, a tetracontapeptide has forty amino acids, etc.
Different Types of Peptides (Classes)
Ribosomal peptides – Ribosomal peptides are synthesized by the translation of mRNA and are often subject to proteolysis to generate the mature form. These function, typically in higher organisms, as hormones and signaling molecules (antibiotics, such as microcins). Due to translational restrictions, the amino acid residues involved are only those used by the ribosome. These peptides frequently have post-translational modifications, such as glycosylation or disulfide formation. They are typically linear, although more exotic manipulations do occur, such as racemization of L-amino acids to D-amino acids.
Nonribosomal peptides – These peptides are assembled by peptide-specific enzymes, not by the ribosome. Nonribosomal peptides are frequently cyclic and can have highly complex cyclic structures, although linear nonribosomal peptides are also common. Since the system is related to the machinery for building fatty acids and polyketides, hybrid compounds are often found, while the presence of oxazoles or thiazoles may indicate that the compound was synthesized in this way.
Milk peptides – Milk peptides are formed from milk proteins by enzymatic breakdown by digestive enzymes or by the proteinases formed by lactobacilli during the fermentation of milk.
Peptones – These peptides are derived from animal milk or meat digested by proteolytic digestion.
Peptide fragments – These peptides are fragments of proteins that are used to calculate data related to the source protein. Peptide fragments are commonly the products of enzymatic degradation performed in the laboratory on a controlled sample, but can also be degraded by natural effects. Such an example is AOD9604, more commonly referred to as Human Growth Hormone (hGH) Fragment 177-191.
Peptide Purity HPLC and Mass Spectrometry
HPLC (High-performance liquid chromatography) and MS (Mass Spectrometry) are implemented during peptide synthesis steps to check the purity content and mass content of the sample, respectively. HPLC is commonly performed multiple times during peptide synthesis if a highly purified peptide is required. Mass spectrometry is used to display the analytical results of the molar mass (molecular weight) of the final result from lyophilization of peptide synthesis.
Understanding Peptide Purity Before You Order!
Peptide purity commonly ranges from >70% (greater than 70% purity) to >99% (greater than 99% purity). The purity level is selected by the company that is requesting custom peptide synthesis and this varies based on the required use of the peptides. Peptides with a purity greater than 70% are nearly always used for testing antibodies and peptides with purity level greater than 85% are typically utilized for enzymology or biological activity studies. Peptides with purity greater than 95% are excellent for quantitative analysis. Peptides are provided with a purity greater than 98% in large quantities with commercial applications for industrial suppliers and are suitable for animal use and non-clinical research use.
Is it Legal to Buy Peptides?
Peptides are legal to buy in the United States and in most countries worldwide for research use only. This means that the peptides are not intended for human and/or animal use and are for laboratory experimentation purposes (non-therapeutic). All peptides sold by GHPeptides.com are FOR RESEARCH USE ONLY and these peptides are not for human intake, but rather drug development or cell culture studies, laboratory experimentation, etc.