IGF-1 LR3, also known as Long-Arginine-3-IGF-1, is an analogue of human IGF-1 that has been modified to include a 13 amino acid N-terminus extension and the substitution of Arginine for Glutamic Acid at position 3. As a result of these modifications, IGF-1 LR3 is approximately three times more potent than IGF-1 and possesses an increased half-life due to lowered affinity for binding to the Insulin-Like Growth Factor-Binding Proteins (IGFBPs). IGF-1 LR3 retains the ability to bind agonistically to the IGF-1 receptor with improved metabolic stability, relative to IGF-1. The supplementation of mammalian cell cultures with Long R3 IGF-1 at a much lower concentration results in more highly elevated productivity than with standard concentrations of insulin and/or standard IGF-1. IGF-1 LR3 is more able to stimulate the type 1 IGF receptor and thus induce a higher level of activation of intracellular signaling, which is responsible for promoting cell proliferation and the inhibition of apoptosis.
Purity, Formulation & Physical Appearance
GHPeptides™ IGF-1 Long R3 has a purity level that exceeds 98.0% as determined by SDS-PAGE Analysis. This peptide was synthesized with no additives and is supplied as a white lyophilized (freeze-dried) powder.
Solubility & Storage
It is recommended to reconstitute the lyophilized IGF-1 Long R3 in sterile water, which can then be further diluted in other aqueous solutions. Lyophilized IGF-1 Long R3 although stable at room temperature for 3-4 weeks, should be stored desiccated below -18°C. Upon reconstitution, IGF-1 Long R3 should be stored at 4°C out of direct light for between 10-14 days and for future use below -18°C. Prevent repeated freeze-thaw cycles.
This product has been synthesized for in-vitro laboratory studies to be performed with cells or biological molecules. This product is not a drug and has not been approved by the FDA to prevent or cure any medical condition or disease. The purchaser is solely liable for risk involved with using this product for any purpose outside of in vitro studies.
- Synonyms: IGF-1 LR3
- Molecular Formula: C400H625N111O115S9
- Molar Mass: 9117.5 Da (g/mol)
- Amino Acid Sequence: